

This was the first edition of Wimbledon to feature a champions tie-break (10-point tie-break), when the score reaches six games all in the fifth set, and the third edition to feature a final set tie-break. It was the first time two left-handed men (Norrie and Nadal) had reached the semi-finals since John McEnroe and Goran Ivanišević in 1992, and to the semi-finals of any major since Nadal and Jürgen Melzer at the 2010 French Open. Cameron Norrie became the fourth British man in the Open Era (after Roger Taylor, Tim Henman, and Andy Murray) to reach the semi-finals.

It was the first time a man had withdrawn from Wimbledon before a semi-final or final since Frank Shields in 1931. Rafael Nadal was attempting to complete the first three components of a Grand Slam, but withdrew before his scheduled semi-final match against Kyrgios due to a torn abdominal muscle. Kyrgios became the first unseeded man to reach a major final since Jo-Wilfried Tsonga at the 2008 Australian Open, the first Australian man to reach a major final since Lleyton Hewitt at the 2005 Australian Open, and the first unseeded or Australian man to reach the Wimbledon final since Mark Philippoussis in 2003.

Because no ranking points were awarded for the tournament in response to its banning of Russian and Belarusian players, Djokovic dropped out of the top five in ATP rankings after the tournament. Djokovic also became the first player (male or female) to win 80 matches at all four majors with his first-round win over Kwon Soon-woo. By reaching his 32nd men's singles major final, he surpassed the all-time record he had jointly held with Roger Federer. Djokovic became the fifth man in the Open Era to record a streak of at least four consecutive titles at one major.

It was his seventh Wimbledon title and 21st major singles title overall. Three-time defending champion Novak Djokovic defeated Nick Kyrgios in the final, 4–6, 6–3, 6–4, 7–6 (7–3) to win the gentlemen's singles tennis title at the 2022 Wimbledon Championships.
